Brands Names: Cialis, Adcirca, Tadacip
Price Range: $0.88 – $1.5
Dosage: 20mg / 10mg / 5mg / 2.5mg
Cialis is one of the three most prescribed pharmacotherapies aimed at treating erectile dysfunction. Worldwide, nearly one out of two men between the ages of 30 to 45 years suffers from erectile dysfunction, and with increasing age prevalence worsens.
Erectile dysfunction (ED) has been defined by Physicians as a persistent (i.e., >3 consecutive months) inability to achieve and/or maintain a full erection for sexual intercourse. Accumulating evidence based on scientific research and clinical trials suggests that there is a global prevalence of this disease.
The main active ingredient of Cialis (as well as Generic Cialis) is tadalafil.
Cialis is produced in tablet form and commonly prescribed in dosages of 5mg to 20mg. The minimal dose of Cialis is 2.5mg
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Effect of Cialis
In contrast to similar drugs used to treat erectile dysfunction like Viagra, the effect of Cialis may last up to 36 hours, which enables you to feel more relaxed in bed.
Following ingestion, the active ingredient in Cialis is quickly absorbed within the digestive tract. The therapeutic concentration of tadalafil (i.e., active ingredient) is fully absorbed in blood within 30 to 120 min.
Effects of Cialis are not known to be influenced by concurrent food consumption. However, evidence from clinical studies suggests that ingestion of too many fatty foods and alcohol can slow the absorption of tadalafil within the gastrointestinal tract.
The half-life of tadalafil is on average 17.5 hours. Tadalafil can be detected in the inactive form throughout the digestive system (up to 65%) and in urine (35%).
The potential side effects associated with the use of Cialis have been studied in nearly 5,000 healthy men worldwide. Reports have indicated that roughly 3% of users of Cialis had to stop taking the medication because of side effects.
In few cases, the following minor side effects or symptoms have been associated with taking Cialis:
- dyspepsia, which includes flatulence, stool disorders, rumbling and discomfort in the stomach, eructation, and/or nausea;
- pain in the back, hands, and feet;
- rhinitis, not associated with allergies or respiratory diseases;
- hot flashes and sweating;
- changes in color perception (noted in less than 0.1% of patients);
- increased fatigue;
- tachycardia and associated palpitations;
- fluctuations in blood pressure;
- hypotension with a change in body position;
- chest pain (angina);
- skin rashes and/or spontaneous erections not associated with sexual intercourse.
Possible symptoms associated with Cialis overdose have been attempted to be simulated in controlled laboratory conditions. However, it has been observed that even while ingesting 500 mg of tadalafil as a single dose or 100 mg several times a day in healthy men, the incidence of adverse events did not exceed the severity of side effects associated with consumption of standard dosages.
Common contraindications associated with prescribing Cialis for the treatment of erectile dysfunction are:
- high risk of an allergic reaction to tadalafil;
- lactose intolerance;
- heart attack or stroke risk;
- angina pectoris;
- chronic heart failure;
- loss of vision associated with ischemic impairment.
When other medications are consumed while taking tadalafil the following points should be considered:
- use of Cialis is contraindicated if already taking organic nitrates because of high risks associated with cardiovascular system complications;
- Cialis is not compatible with other medications taken for the treatment of erectile dysfunction;
- ketoconazole, itraconazole, and other medications associated with HIV therapy may increase the effects of Cialis;
- rifampicin, phenobarbital, and carbamazepine inhibit the activity of tadalafil;
- concurrent ingestion of antacids does not affect the potency of Cialis, but may reduce the rate of absorption;
- tadalafil modestly increases the effects of antihypertensive pharmacotherapies.
Even when used over long durations of time, the drug insert packet for Cialis indicates that this medication is not addictive.
Instructions for the use of Cialis are as follows:
- with an active sexual life (i.e., sex occurs >2 times per week) take 5 mg per day. Cialis should be taken at the same time each day irrespective of concurrent food consumption;
- with low sexual activity (i.e., ≤2 times per week), one tablet of Cialis should be taken at a dosage of tadalafil equal to 20 mg approximately 30 to 40 minutes prior to engaging in sexual intercourse.
For the complex treatment of inflammation of the prostate, Cialis may also be taken in 5 mg doses once a day.